Sedation with non sedating antihistamines Freesexchat no registration
Many mothers are required to use drugs during breastfeeding.Almost all drugs transfer into breast milk and this may carry a risk to a breastfed infant.For drugs that have an infant dose greater than the arbitrary cut-off of 10% of the weight-adjusted maternal dose, it may be reasonable to reduce infant exposure by alternating breast and bottle-feeding.For drugs that are not considered safe in breastfeeding, breast milk may be expressed and discarded for the treatment duration.Other factors to consider in conjunction with the infant's dose include the pharmacokinetics of the drug in the infant.Generally, drugs that are poorly absorbed or have high first-pass metabolism are less likely to be problematical during breastfeeding.
However, for some drugs, milk concentrations lag behind plasma concentrations.
The infant dose (mg/kg) can then be expressed as a percentage of the maternal dose (mg/kg).
An arbitrary cut-off of 10% has been selected as a guide to the safe use of drugs during lactation.
Generally, adult glomerular filtration rates (adjusted for the difference in surface area) are attained by five to six months of age.
Metabolic processes such as phase 1 oxidation and phase 2 glucuronidation are also impaired in the neonate.